Cross-frame designs and layouts for longer-span and severely skewed bridges can challenge designers. However, the 10th Edition of the AASHTO LRFD Specifications contains various new requirements for assessing the adequacy of stability bracing and global bridge stability in I-girder structural systems. Similarly, advances have been made in tools available to evaluate the global stability of longer-span bridges and/or innovative framing arrangements. This session will focus on new analysis tools that enable designers to directly assess the stability requirements and a case study demonstrating the cross-frame design and layout for a severely skewed steel bridge and how the AASHTO 10th Edition would have influenced the design.